Minimizing Ischemia Reperfusion Injury in Xenotransplantation

Parth M. Patel; Margaret R. Connolly; Taylor M. Coe; Anthony Calhoun; Anthony Calhoun; Franziska Pollok; Franziska Pollok; James F. Markmann; James F. Markmann; Lars Burdorf; Lars Burdorf; Agnes Azimzadeh; Agnes Azimzadeh; Joren C. Madsen; Joren C. Madsen; Richard N. Pierson; Richard N. Pierson

doi:10.3389/fimmu.2021.681504

Frontiers in Immunology (Sep 2021)

Minimizing Ischemia Reperfusion Injury in Xenotransplantation

Parth M. Patel,
Margaret R. Connolly,
Taylor M. Coe,
Anthony Calhoun,
Anthony Calhoun,
Franziska Pollok,
Franziska Pollok,
James F. Markmann,
James F. Markmann,
Lars Burdorf,
Lars Burdorf,
Agnes Azimzadeh,
Agnes Azimzadeh,
Joren C. Madsen,
Joren C. Madsen,
Richard N. Pierson,
Richard N. Pierson

Affiliations

Parth M. Patel: Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States
Margaret R. Connolly: Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States
Taylor M. Coe: Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States
Anthony Calhoun: Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States
Anthony Calhoun: Department of Surgery, Division of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States
Franziska Pollok: Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States
Franziska Pollok: Department of Anesthesiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany
James F. Markmann: Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States
James F. Markmann: Department of Surgery, Division of Transplantation, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States
Lars Burdorf: Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States
Lars Burdorf: Department of Surgery, Division of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States
Agnes Azimzadeh: Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States
Agnes Azimzadeh: Department of Surgery, Division of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States
Joren C. Madsen: Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States
Joren C. Madsen: Department of Surgery, Division of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States
Richard N. Pierson: Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States
Richard N. Pierson: Department of Surgery, Division of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States

DOI: https://doi.org/10.3389/fimmu.2021.681504
Journal volume & issue: Vol. 12

Abstract

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The recent dramatic advances in preventing “initial xenograft dysfunction” in pig-to-non-human primate heart transplantation achieved by minimizing ischemia suggests that ischemia reperfusion injury (IRI) plays an important role in cardiac xenotransplantation. Here we review the molecular, cellular, and immune mechanisms that characterize IRI and associated “primary graft dysfunction” in allotransplantation and consider how they correspond with “xeno-associated” injury mechanisms. Based on this analysis, we describe potential genetic modifications as well as novel technical strategies that may minimize IRI for heart and other organ xenografts and which could facilitate safe and effective clinical xenotransplantation.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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