PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes

Phong Lan Thao Tran; Thomas J. Pohl; Chi-Fu Chen; Angela Chan; Sebastian Pott; Virginia A. Zakian

doi:10.1038/ncomms15025

Nature Communications (Apr 2017)

PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes

Phong Lan Thao Tran,
Thomas J. Pohl,
Chi-Fu Chen,
Angela Chan,
Sebastian Pott,
Virginia A. Zakian

Affiliations

Phong Lan Thao Tran: Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University
Thomas J. Pohl: Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University
Chi-Fu Chen: Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University
Angela Chan: Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University
Sebastian Pott: Department of Human Genetics, University of Chicago
Virginia A. Zakian: Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University

DOI: https://doi.org/10.1038/ncomms15025
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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The budding yeast genome encodes two Pif1 family helicases, Pif1 and Rrm3, previously shown to have distinct functions in the maintenance of telomeres and other aspects of genome stability. Here the authors identify a role for Pif1 (and Rrm3) in promoting DNA replication and suppressing R-loop mediated DNA damage at tRNA genes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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