In Vitro Antileishmanial Activity of Sterols from Trametes versicolor (Bres. Rivarden)

Vivian Leliebre-Lara; Lianet Monzote Fidalgo; Eva-Maria Pferschy-Wenzig; Olaf Kunert; Clara Nogueiras Lima; Rudolf Bauer

doi:10.3390/molecules21081045

Molecules (Aug 2016)

In Vitro Antileishmanial Activity of Sterols from Trametes versicolor (Bres. Rivarden)

Vivian Leliebre-Lara,
Lianet Monzote Fidalgo,
Eva-Maria Pferschy-Wenzig,
Olaf Kunert,
Clara Nogueiras Lima,
Rudolf Bauer

Affiliations

Vivian Leliebre-Lara: Centre for Natural Product Studies, Faculty of Chemistry, University of Havana, Zapata y G, La Habana 10400, Cuba
Lianet Monzote Fidalgo: Parasitology Department, Institute of Tropical Medicine “Pedro Kouri” Marianao 13, Havana 10400, Cuba
Eva-Maria Pferschy-Wenzig: Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Universitaetsplatz 4, 8010 Graz, Austria
Olaf Kunert: Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Graz, Universitaetsplatz 4, 8010 Graz, Austria
Clara Nogueiras Lima: Centre for Natural Product Studies, Faculty of Chemistry, University of Havana, Zapata y G, La Habana 10400, Cuba
Rudolf Bauer: Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Universitaetsplatz 4, 8010 Graz, Austria

DOI: https://doi.org/10.3390/molecules21081045
Journal volume & issue: Vol. 21, no. 8
p. 1045

Abstract

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Two ergostanes, 5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol (1) and 5α-ergost-7,22-dien-3β-ol (2), and a lanostane, 3β-hydroxylanostan-8,24-diene-21-oic acid (trametenolic acid) (3), were isolated from an n-hexane extract prepared from the fruiting body of Trametes versicolor (Bres. Rivarden). The activity of the isolated sterols was evaluated against promastigotes and amastigotes of Leishmania amazonensis Lainson and Shaw, 1972. The lanostane, compound (3), showed the best inhibitory response (IC50 promastigotes 2.9 ± 0.1 μM and IC50 amastigotes 1.6 ± 0.1 μM). This effect was 25-fold higher compared with its cytotoxic effect on peritoneal macrophages from BALB/c mice. Therefore, trametenolic acid could be regarded as a promising lead for the synthesis of compounds with antileishmanial activity.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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