Nature Communications (Jul 2022)
Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension
- Markus M. Rinschen,
- Oleg Palygin,
- Ashraf El-Meanawy,
- Xavier Domingo-Almenara,
- Amelia Palermo,
- Lashodya V. Dissanayake,
- Daria Golosova,
- Michael A. Schafroth,
- Carlos Guijas,
- Fatih Demir,
- Johannes Jaegers,
- Megan L. Gliozzi,
- Jingchuan Xue,
- Martin Hoehne,
- Thomas Benzing,
- Bernard P. Kok,
- Enrique Saez,
- Markus Bleich,
- Nina Himmerkus,
- Ora A. Weisz,
- Benjamin F. Cravatt,
- Marcus Krüger,
- H. Paul Benton,
- Gary Siuzdak,
- Alexander Staruschenko
Affiliations
- Markus M. Rinschen
- Scripps Center for Metabolomics, Scripps Research
- Oleg Palygin
- Division of Nephrology, Department of Medicine, Medical University of South Carolina
- Ashraf El-Meanawy
- Division of Nephrology, Department of Medicine, Medical College of Wisconsin
- Xavier Domingo-Almenara
- Scripps Center for Metabolomics, Scripps Research
- Amelia Palermo
- Scripps Center for Metabolomics, Scripps Research
- Lashodya V. Dissanayake
- Department of Molecular Pharmacology and Physiology, University of South Florida
- Daria Golosova
- Department of Physiology, Medical College of Wisconsin
- Michael A. Schafroth
- Department of Chemistry, Scripps Research
- Carlos Guijas
- Scripps Center for Metabolomics, Scripps Research
- Fatih Demir
- Department of Biomedicine, Aarhus University
- Johannes Jaegers
- Department of Biomedicine, Aarhus University
- Megan L. Gliozzi
- Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine
- Jingchuan Xue
- Scripps Center for Metabolomics, Scripps Research
- Martin Hoehne
- Center for Molecular Medicine Cologne
- Thomas Benzing
- Center for Molecular Medicine Cologne
- Bernard P. Kok
- Department of Molecular Medicine, Scripps Research
- Enrique Saez
- Department of Molecular Medicine, Scripps Research
- Markus Bleich
- Institute of Physiology, University Kiel
- Nina Himmerkus
- Institute of Physiology, University Kiel
- Ora A. Weisz
- Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine
- Benjamin F. Cravatt
- Department of Chemistry, Scripps Research
- Marcus Krüger
- Center for Molecular Medicine Cologne
- H. Paul Benton
- Scripps Center for Metabolomics, Scripps Research
- Gary Siuzdak
- Scripps Center for Metabolomics, Scripps Research
- Alexander Staruschenko
- Department of Molecular Pharmacology and Physiology, University of South Florida
- DOI
- https://doi.org/10.1038/s41467-022-31670-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Kidney metabolism in disease is important but not well understood. Here, using isotope-guided metabolomics, the authors show that lysine’s metabolic activity conveys kidney protection in hypertension through accelerated metabolism and physiological effects on tubular function.
