Nature Communications (Sep 2018)
RNA editing derived epitopes function as cancer antigens to elicit immune responses
- Minying Zhang,
- Jens Fritsche,
- Jason Roszik,
- Leila J. Williams,
- Xinxin Peng,
- Yulun Chiu,
- Chih-Chiang Tsou,
- Franziska Hoffgaard,
- Valentina Goldfinger,
- Oliver Schoor,
- Amjad Talukder,
- Marie A. Forget,
- Cara Haymaker,
- Chantale Bernatchez,
- Leng Han,
- Yiu-Huen Tsang,
- Kathleen Kong,
- Xiaoyan Xu,
- Kenneth L. Scott,
- Harpreet Singh-Jasuja,
- Greg Lizee,
- Han Liang,
- Toni Weinschenk,
- Gordon B. Mills,
- Patrick Hwu
Affiliations
- Minying Zhang
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Jens Fritsche
- Immatics Biotechnologies
- Jason Roszik
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Leila J. Williams
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Xinxin Peng
- Department of Bioinformatics and Computation Biology, The University of Texas MD Anderson Cancer Center
- Yulun Chiu
- Department of Bioinformatics and Computation Biology, The University of Texas MD Anderson Cancer Center
- Chih-Chiang Tsou
- Immatics US
- Franziska Hoffgaard
- Immatics Biotechnologies
- Valentina Goldfinger
- Immatics Biotechnologies
- Oliver Schoor
- Immatics Biotechnologies
- Amjad Talukder
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Marie A. Forget
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Cara Haymaker
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Chantale Bernatchez
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Leng Han
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School
- Yiu-Huen Tsang
- Department of Molecular and Human Genetics, Baylor College of Medicine
- Kathleen Kong
- Department of Molecular and Human Genetics, Baylor College of Medicine
- Xiaoyan Xu
- Department of Bioinformatics and Computation Biology, The University of Texas MD Anderson Cancer Center
- Kenneth L. Scott
- Department of Molecular and Human Genetics, Baylor College of Medicine
- Harpreet Singh-Jasuja
- Immatics Biotechnologies
- Greg Lizee
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Han Liang
- Department of Bioinformatics and Computation Biology, The University of Texas MD Anderson Cancer Center
- Toni Weinschenk
- Immatics Biotechnologies
- Gordon B. Mills
- Department of Systems Biology, The University of Texas MD Anderson Cancer Center
- Patrick Hwu
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-018-06405-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 10
Abstract
RNA editing is a biological process that creates sequence variation. Here the authors show that peptides generated as a consequence of RNA editing are naturally presented by human leukocyte antigen (HLA) and serve as antigens to elicit anti-tumour immune responses.
