Evaluation of the Effect of Primary and Secondary Closure on the Use of Leukocyte and Platelet-Rich Fibrin in Impacted Lower Third Molar Surgery

Abstract

The aim of this study was to compare the effect of using L-PRF in patients undergoing impacted lower third molar surgery with either primary or secondary closure techniques. Methods: This prospective, randomized, double-blind, split-mouth clinical trial was conducted on patients with bilateral impacted lower third molars of a similar position. Primary closure was performed in group 1 and secondary closure in group 2. The group 1 closure technique was applied to one side of the patients, and the group 2 closure technique was applied to the other side at different times. Of the 45 patients evaluated, 9 patients were excluded from the study because of alveolitis and failure to attend regular control visits out. Results: Of the 36 patients included in the study, 23 were female and 13 were male, with a mean age of 22.42 ± 3.36 years. The secondary closure group had lower VAS scores at hour 6 (p p < 0.05). Conclusions: The results of this study, showing that both secondary and primary closure are effective, with similar outcomes in terms of pain, swelling, and trismus, should be supported by future clinical trials.

Keywords

• leukocyte and platelet-rich fibrin
• closure techniques
• wound healing
• regenerative medicine
• primary closure
• secondary closure