Information decay and enzymatic information recovery for DNA data storage

Linda C. Meiser; Andreas L. Gimpel; Tejas Deshpande; Gabriela Libort; Weida D. Chen; Reinhard Heckel; Bichlien H. Nguyen; Karin Strauss; Wendelin J. Stark; Robert N. Grass

doi:10.1038/s42003-022-04062-9

Communications Biology (Oct 2022)

Information decay and enzymatic information recovery for DNA data storage

Linda C. Meiser,
Andreas L. Gimpel,
Tejas Deshpande,
Gabriela Libort,
Weida D. Chen,
Reinhard Heckel,
Bichlien H. Nguyen,
Karin Strauss,
Wendelin J. Stark,
Robert N. Grass

Affiliations

Linda C. Meiser: Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich
Andreas L. Gimpel: Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich
Tejas Deshpande: Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich
Gabriela Libort: Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich
Weida D. Chen: Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich
Reinhard Heckel: Department of Electrical and Computer Engineering, Technical University of Munich
Bichlien H. Nguyen: Microsoft Research
Karin Strauss: Microsoft Research
Wendelin J. Stark: Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich
Robert N. Grass: Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich

DOI: https://doi.org/10.1038/s42003-022-04062-9
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 9

Abstract

Read online

An enzymatic repair system is described which repairs nicked DNA in DNA libraries, and simulations of damage and repair suggests this enzymatic repair step is beneficial for DNA data storage.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal