Ultra-long-acting removable drug delivery system for HIV treatment and prevention

Martina Kovarova; S. Rahima Benhabbour; Ivana Massud; Rae Ann Spagnuolo; Brianna Skinner; Caroline E. Baker; Craig Sykes; Katie R. Mollan; Angela D. M. Kashuba; J. Gerardo García-Lerma; Russell J. Mumper; J. Victor Garcia

doi:10.1038/s41467-018-06490-w

Nature Communications (Oct 2018)

Ultra-long-acting removable drug delivery system for HIV treatment and prevention

Martina Kovarova,
S. Rahima Benhabbour,
Ivana Massud,
Rae Ann Spagnuolo,
Brianna Skinner,
Caroline E. Baker,
Craig Sykes,
Katie R. Mollan,
Angela D. M. Kashuba,
J. Gerardo García-Lerma,
Russell J. Mumper,
J. Victor Garcia

Affiliations

Martina Kovarova: Division of Infectious Diseases, Center for AIDS Research, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill
S. Rahima Benhabbour: Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill
Ivana Massud: Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention
Rae Ann Spagnuolo: Division of Infectious Diseases, Center for AIDS Research, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill
Brianna Skinner: Comparative Medicine Branch, Division of Scientific Resources, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention
Caroline E. Baker: Division of Infectious Diseases, Center for AIDS Research, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill
Craig Sykes: Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill
Katie R. Mollan: The University of North Carolina Center for AIDS Research
Angela D. M. Kashuba: Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill
J. Gerardo García-Lerma: Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention
Russell J. Mumper: Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill
J. Victor Garcia: Division of Infectious Diseases, Center for AIDS Research, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill

DOI: https://doi.org/10.1038/s41467-018-06490-w
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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Long-acting (LA) formulations of antiretroviral (ARV) drugs are an alternative approach to improve adherence for HIV treatment and prevention. Here the authors show a removable biodegradable ultra-LA-ARV drug system that effectively delivers drug, controls viremia and prevents infection in animal models of HIV infection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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