Nature Communications (Oct 2022)

Salience memories formed by value, novelty and aversiveness jointly shape object responses in the prefrontal cortex and basal ganglia

  • Ali Ghazizadeh,
  • Okihide Hikosaka

DOI
https://doi.org/10.1038/s41467-022-33514-3
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 14

Abstract

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How object salience is encoded in the cortex and basal ganglia remains incompletely understood. Here, the authors show that individual prefrontal cortex neurons are jointly sensitive to the memory of value, aversiveness, novelty, and recency of objects, while the substantia nigra reticulata filters out novelty and recency signals but amplifies value and aversive memories.