Role of soluble gp130 in the tumour necrosis factor-α expression and its production by peripheral blood mononuclear cells

E. Jablonskaca; W. Puzewska; M. Marcinczyk; J. Jablonski

doi:10.1080/09629350310001633397

Mediators of Inflammation (Jan 2003)

Role of soluble gp130 in the tumour necrosis factor-α expression and its production by peripheral blood mononuclear cells

E. Jablonskaca,
W. Puzewska,
M. Marcinczyk,
J. Jablonski

Affiliations

E. Jablonskaca: Department of Immunology, Medical University of Bialystok, Waszyngtona 15A, Bialystok 15-274, Poland
W. Puzewska: Department of Immunology, Medical University of Bialystok, Waszyngtona 15A, Bialystok 15-274, Poland
M. Marcinczyk: Department of Immunology, Medical University of Bialystok, Waszyngtona 15A, Bialystok 15-274, Poland
J. Jablonski: Department of Toxicology, Medical University of Bialystok, Waszyngtona 15A, Bialystok 15-274, Poland

DOI: https://doi.org/10.1080/09629350310001633397
Journal volume & issue: Vol. 12, no. 6
pp. 355 – 359

Abstract

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Background: In our previous study we found that rhsIL-6R, along with recombinant human interleukin-6, plays a regulatory role in the immune response by modulating the tumour necrosis factor-α (TNF-α) expression and its production by peripheral blood mononuclearcells (PBMC). We also suggested that sIL-6R with IL-6 secreted by human PMN (neutrophils) influenced the TNF-α expression and its production by autologous PBMC.

Published in Mediators of Inflammation

ISSN: 0962-9351 (Print); 1466-1861 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Pathology
Website: https://www.hindawi.com/journals/mi/

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