Coexistence of trisomy 12 and del(13)(q14.3) in two patients with chronic lymphocytic leukemia

Abstract

We describe two patients with diagnosis of chronic lymphocytic leukemia (CLL) in whom interphase fluo­rescence in situ hybridization (FISH) analysis revealed trisomy 12 and del(13)(q14.3) occurring in the same clone. These abnormalities are rarely seen together and the prognostic relevance of their coexistence is still unclear. According to some data, a probable adverse prognosis for this group of patients is suggested. Our patients have been in a stable phase of the disease for more than one year since the given abnormalities were documented in their karyotypes. Further study is necessary to determine the prognostic significance of coexistence of these abnormalities in CLL patients.

Keywords

• Chronic lymphocytic leukemia
• trisomy 12,13q deletion
• chromosomal abnormalities
• FISH