Protein profile of different cellular fractions from Mycobacterium tuberculosis strains after exposure to isoniazid

Luisa María Nieto Ramirez; Carolina Mehaffy; Karen M. Dobos

Data in Brief (Jun 2019)

Protein profile of different cellular fractions from Mycobacterium tuberculosis strains after exposure to isoniazid

Luisa María Nieto Ramirez,
Carolina Mehaffy,
Karen M. Dobos

Affiliations

Luisa María Nieto Ramirez: Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA; Universidad Santiago de Cali, Cali, Colombia
Carolina Mehaffy: Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA
Karen M. Dobos: Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA; Corresponding author.

Journal volume & issue: Vol. 24

Abstract

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Different biochemical studies looking for the effect of INH on the physiology of Mycobacterium tuberculosis (Mtb) have been conducted. Here, we present a detailed analysis, looking at the protein variation in the Mtb cell due to exposure of sub-inhibitory concentrations of INH, evaluating three different variables: cellular fraction, genetic lineage, and INH phenotypic profile. Mass spectrometry analysis demonstrated that the most significantly affected cellular fraction was the membrane and the INH resistant strains showed the highest number of proteins altered when they were exposed to INH. Raw data are available via ProteomeXchange with identifier PXD007588.

Published in Data in Brief

ISSN: 2352-3409 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Computer applications to medicine. Medical informatics; Science: Science (General)
Website: http://www.journals.elsevier.com/data-in-brief/

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