Role of Neutrophil-to-Lymphocyte Ratio (NLR) in Patients with Mycosis Fungoides

Cosimo Di Raimondo; Paolo Lombardo; Cristiano Tesei; Fabiana Esposito; Federico Meconi; Roberto Secchi; Flavia Lozzi; Alessandro Monopoli; Maria Grazia Narducci; Enrico Scala; Cecilia Angeloni; Alberto De Stefano; Siavash Rahimi; Luca Bianchi; Maria Cantonetti

doi:10.3390/diagnostics13111979

Diagnostics (Jun 2023)

Role of Neutrophil-to-Lymphocyte Ratio (NLR) in Patients with Mycosis Fungoides

Cosimo Di Raimondo,
Paolo Lombardo,
Cristiano Tesei,
Fabiana Esposito,
Federico Meconi,
Roberto Secchi,
Flavia Lozzi,
Alessandro Monopoli,
Maria Grazia Narducci,
Enrico Scala,
Cecilia Angeloni,
Alberto De Stefano,
Siavash Rahimi,
Luca Bianchi,
Maria Cantonetti

Affiliations

Cosimo Di Raimondo: Department of Dermatology, University of Roma Tor Vergata, 00133 Rome, Italy
Paolo Lombardo: Istituto Dermopatico dell’Immacolata, IDI-IRCCS, 00167 Rome, Italy
Cristiano Tesei: Department of Hematology, University of Roma Tor Vergata, 00133 Rome, Italy
Fabiana Esposito: Department of Hematology, University of Roma Tor Vergata, 00133 Rome, Italy
Federico Meconi: Department of Hematology, University of Roma Tor Vergata, 00133 Rome, Italy
Roberto Secchi: Department of Hematology, University of Roma Tor Vergata, 00133 Rome, Italy
Flavia Lozzi: Department of Dermatology, University of Roma Tor Vergata, 00133 Rome, Italy
Alessandro Monopoli: Istituto Dermopatico dell’Immacolata, IDI-IRCCS, 00167 Rome, Italy
Maria Grazia Narducci: Istituto Dermopatico dell’Immacolata, IDI-IRCCS, 00167 Rome, Italy
Enrico Scala: Istituto Dermopatico dell’Immacolata, IDI-IRCCS, 00167 Rome, Italy
Cecilia Angeloni: Department of Diagnostic Imaging and Interventional Radiology, University of Roma Tor Vergata, 00133 Rome, Italy
Alberto De Stefano: Volunteers Association of Fondazione Policlinico “Tor Vergata”, 00133 Rome, Italy
Siavash Rahimi: Istituto Dermopatico dell’Immacolata, IDI-IRCCS, 00167 Rome, Italy
Luca Bianchi: Department of Dermatology, University of Roma Tor Vergata, 00133 Rome, Italy
Maria Cantonetti: Istituto Dermopatico dell’Immacolata, IDI-IRCCS, 00167 Rome, Italy

DOI: https://doi.org/10.3390/diagnostics13111979
Journal volume & issue: Vol. 13, no. 11
p. 1979

Abstract

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Background: The neutrophil/lymphocyte ratio (NLR) at baseline has been demonstrated to correlate with higher stages of disease and to be a prognostic factor in numerous cancers. However, its function as a prognostic factor for mycosis fungoides (MF) has not been yet clarified. Objective: Our work aimed to assess the association of the NLR with different stages of MF and to outline whether higher values of this marker are related to a more aggressive MF. Methods: We retrospectively calculated the NLRs in 302 MF patients at the moment of diagnosis. The NLR was obtained using the complete blood count values. Results: The median NLR among patients with early stage disease (low-grade IA-IB-IIA) was 1.88, while the median NLR for patients with high-grade MF (IIB-IIIA-IIIB) was 2.64. Statistical analysis showed positive associations of advanced MF stages with NLRs higher than 2.3. Conclusions: Our analysis demonstrates that the NLR represents a cheap and easily available parameter functioning as a marker for advanced MF. This might guide physicians in recognizing patients with advanced stages of disease requiring a strict follow-up or an early treatment.

Published in Diagnostics

ISSN: 2075-4418 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General)
Website: http://www.mdpi.com/journal/diagnostics

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