Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens

Erin W. Meermeier; Bruno F. Laugel; Andrew K. Sewell; Alexandra J. Corbett; Jamie Rossjohn; James McCluskey; Melanie J. Harriff; Tamera Franks; Marielle C. Gold; David M. Lewinsohn

doi:10.1038/ncomms12506

Nature Communications (Aug 2016)

Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens

Erin W. Meermeier,
Bruno F. Laugel,
Andrew K. Sewell,
Alexandra J. Corbett,
Jamie Rossjohn,
James McCluskey,
Melanie J. Harriff,
Tamera Franks,
Marielle C. Gold,
David M. Lewinsohn

Affiliations

Erin W. Meermeier: Department of Molecular Microbiology and Immunology, Oregon Health and Science University
Bruno F. Laugel: Institute of Infection and Immunity, Henry Wellcome Research Institute, Cardiff University School of Medicine
Andrew K. Sewell: Institute of Infection and Immunity, Henry Wellcome Research Institute, Cardiff University School of Medicine
Alexandra J. Corbett: Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
Jamie Rossjohn: Institute of Infection and Immunity, Henry Wellcome Research Institute, Cardiff University School of Medicine
James McCluskey: Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
Melanie J. Harriff: Department of Pulmonary and Critical Care Medicine, Oregon Health and Science University
Tamera Franks: Department of Research, VA Portland Health Care Center
Marielle C. Gold: Department of Molecular Microbiology and Immunology, Oregon Health and Science University
David M. Lewinsohn: Department of Molecular Microbiology and Immunology, Oregon Health and Science University

DOI: https://doi.org/10.1038/ncomms12506
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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Mucosal-associated invariant T (MAIT) cells sense riboflavin biosynthetic intermediate antigens with a semi-invariant MR1-restricted T-cell receptor (TCR). Here the authors identify a new MR1-restricted TCR that senses cells infected with S. pyogenes, a bacteria unable to biosynthesize riboflavin.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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