Vaccines (Apr 2023)

Seroprevalence of SARS-CoV-2 and Vaccination Coverage among Residents of a Lower-Middle-Class Population in the Federal District, Brazil

  • Raíssa Nogueira de Brito,
  • Ana Izabel Passarella Teixeira,
  • Carolina Carvalho Gontijo,
  • Rafael Da Silva Faria,
  • Walter Massa Ramalho,
  • Gustavo Adolfo Sierra Romero,
  • Manoel Castro,
  • Vitoria Pessoa,
  • Larissa Araújo Torres,
  • Larissa Pereira Leite,
  • Elza Ferreira Noronha,
  • Rodrigo Haddad,
  • Wildo Navegantes de Araújo

DOI
https://doi.org/10.3390/vaccines11050916
Journal volume & issue
Vol. 11, no. 5
p. 916

Abstract

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Estimating seroprevalence and vaccination coverage against COVID-19 is crucial to the development of well-targeted public health policies at the local level. Here, we estimated seroprevalence and vaccination coverage in a lower-middle-class population in Brazil. We conducted an observational, cross-sectional, population-based survey from 24 September to 19 December 2021. CMIA tests were used to detect anti-SARS-CoV-2 IgG against the N-protein. The overall seroprevalence was 24.15% (177/733), and vaccination coverage was 91.40% (670/733); 72.09% (483/670) were fully vaccinated. Among vaccinated participants, seroprevalence was 24.77% (95% CI 21.50–28.04; 166/670), with a prevalence ratio (PR) of 1.03 (95% CI 0.98–1.08; p-value 0.131). Among participants who received an mRNA vaccine with S-based epitope (485), seroprevalence was 16.29% (95% CI 13.04–19.85; 79/485). Among unvaccinated participants, seroprevalence was 17.46% (95% CI 10.04–28.62; 11/63). Finally, in spite of the political climate and other possible causes for vaccine hesitancy, the positive Brazilian culture towards vaccination might have curbed hesitancy.

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