The expression and function of long noncoding RNAs in hepatocellular carcinoma

Abstract

Abstract With the deepening of the genome project study, attention on noncoding RNAs is increasing. Long noncoding RNAs (lncRNAs) have become a new research hotspot. A growing number of studies have revealed that lncRNAs are involved in tumorigenesis and tumor suppressor pathways. Aberrant expressions of lncRNAs have been found in a variety of human tumors including hepatocellular carcinoma (HCC). In this review, we provide a brief introduction to lncRNA and highlight recent research on the functions and clinical significance of lncRNAs in HCC.

Keywords

• carcinogenesis
• hepatocellular carcinoma
• long noncoding RNA
• noncoding RNAs
• tumor suppressor