The TSPO-NOX1 axis controls phagocyte-triggered pathological angiogenesis in the eye

Anne Wolf; Marc Herb; Michael Schramm; Thomas Langmann

doi:10.1038/s41467-020-16400-8

Nature Communications (Jun 2020)

The TSPO-NOX1 axis controls phagocyte-triggered pathological angiogenesis in the eye

Anne Wolf,
Marc Herb,
Michael Schramm,
Thomas Langmann

Affiliations

Anne Wolf: Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Faculty of Medicine and University Hospital Cologne
Marc Herb: Institute for Medical Microbiology, Immunology and Hygiene
Michael Schramm: Institute for Medical Microbiology, Immunology and Hygiene
Thomas Langmann: Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Faculty of Medicine and University Hospital Cologne

DOI: https://doi.org/10.1038/s41467-020-16400-8
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 17

Abstract

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Age-related macular degeneration (AMD) is a major cause of blindness in the elderly. Here, the authors show that microglia-specific deletion of TSPO and chemical inhibition of TSPO prevent neuroinflammation and vascular damage in a mouse model of AMD.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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