Non-catalytic signaling by pseudokinase ILK for regulating cell adhesion

Julia Vaynberg; Koichi Fukuda; Fan Lu; Katarzyna Bialkowska; Yinghua Chen; Edward F. Plow; Jun Qin

doi:10.1038/s41467-018-06906-7

Nature Communications (Oct 2018)

Non-catalytic signaling by pseudokinase ILK for regulating cell adhesion

Julia Vaynberg,
Koichi Fukuda,
Fan Lu,
Katarzyna Bialkowska,
Yinghua Chen,
Edward F. Plow,
Jun Qin

Affiliations

Julia Vaynberg: Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic
Koichi Fukuda: Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic
Fan Lu: Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic
Katarzyna Bialkowska: Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic
Yinghua Chen: Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University
Edward F. Plow: Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic
Jun Qin: Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic

DOI: https://doi.org/10.1038/s41467-018-06906-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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Pseudokinase ILK is essential for dynamic communication between focal adhesion complexes and F-actin filaments. Here, the authors show that ILK regulates such communication by complexing with PINCH and Parvin to trigger F-actin filament bundling through previously unrecognized actin binding motifs in PINCH and Parvin

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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