Communications Biology (Sep 2022)
Arsenal of nanobodies shows broad-spectrum neutralization against SARS-CoV-2 variants of concern in vitro and in vivo in hamster models
- Martin A. Rossotti,
- Henk van Faassen,
- Anh T. Tran,
- Joey Sheff,
- Jagdeep K. Sandhu,
- Diana Duque,
- Melissa Hewitt,
- Xiaoxue Wen,
- Jegarubee Bavananthasivam,
- Saina Beitari,
- Kevin Matte,
- Geneviève Laroche,
- Patrick M. Giguère,
- Christian Gervais,
- Matthew Stuible,
- Julie Guimond,
- Sylvie Perret,
- Greg Hussack,
- Marc-André Langlois,
- Yves Durocher,
- Jamshid Tanha
Affiliations
- Martin A. Rossotti
- Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada
- Henk van Faassen
- Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada
- Anh T. Tran
- Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada
- Joey Sheff
- Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada
- Jagdeep K. Sandhu
- Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada
- Diana Duque
- Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada
- Melissa Hewitt
- Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada
- Xiaoxue Wen
- Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada
- Jegarubee Bavananthasivam
- Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada
- Saina Beitari
- Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada
- Kevin Matte
- Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa
- Geneviève Laroche
- Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa
- Patrick M. Giguère
- Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa
- Christian Gervais
- Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada
- Matthew Stuible
- Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada
- Julie Guimond
- Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada
- Sylvie Perret
- Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada
- Greg Hussack
- Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada
- Marc-André Langlois
- Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa
- Yves Durocher
- Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada
- Jamshid Tanha
- Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada
- DOI
- https://doi.org/10.1038/s42003-022-03866-z
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 19
Abstract
Isolation and extensive characterization of a collection of 37 anti-SARS-CoV-2 spike glycoprotein nanobodies show broad neutralization efficacies in vitro and in vivo in a hamster model of SARS-CoV-2 infection.
