[<sup>18</sup>F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging

Tanuj Puri; Michelle L. Frost; Gary J. Cook; Glen M. Blake

doi:10.3390/tomography7040071

Tomography (Dec 2021)

[<sup>18</sup>F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging

Tanuj Puri,
Michelle L. Frost,
Gary J. Cook,
Glen M. Blake

Affiliations

Tanuj Puri: Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King’s College London, London SE1 7EH, UK
Michelle L. Frost: Institute of Cancer Research Clinical Trials & Statistics Unit (ICR-CTSU), Institute of Cancer Research, Sutton SM2 5NG, UK
Gary J. Cook: Department of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King’s College London, London SE1 7EH, UK
Glen M. Blake: Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King’s College London, London SE1 7EH, UK

DOI: https://doi.org/10.3390/tomography7040071
Journal volume & issue: Vol. 7, no. 4
pp. 843 – 854

Abstract

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This report describes the significance of the kinetic parameters (k-values) obtained from the analysis of dynamic positron emission tomography (PET) scans using the Hawkins model describing the pharmacokinetics of sodium fluoride ([18F]NaF) to understand bone physiology. Dynamic [18F]NaF PET scans may be useful as an imaging biomarker in early phase clinical trials of novel drugs in development by permitting early detection of treatment-response signals that may help avoid late-stage attrition.

Published in Tomography

ISSN: 2379-1381 (Print); 2379-139X (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General): Computer applications to medicine. Medical informatics
Website: https://www.mdpi.com/journal/tomography

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