Nature Communications (Dec 2021)
Mapping the serum proteome to neurological diseases using whole genome sequencing
- Grace Png,
- Andrei Barysenka,
- Linda Repetto,
- Pau Navarro,
- Xia Shen,
- Maik Pietzner,
- Eleanor Wheeler,
- Nicholas J. Wareham,
- Claudia Langenberg,
- Emmanouil Tsafantakis,
- Maria Karaleftheri,
- George Dedoussis,
- Anders Mälarstig,
- James F. Wilson,
- Arthur Gilly,
- Eleftheria Zeggini
Affiliations
- Grace Png
- Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental Health
- Andrei Barysenka
- Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental Health
- Linda Repetto
- Centre for Global Health Research, Usher Institute, University of Edinburgh
- Pau Navarro
- MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Xia Shen
- Centre for Global Health Research, Usher Institute, University of Edinburgh
- Maik Pietzner
- MRC Epidemiology Unit, University of Cambridge
- Eleanor Wheeler
- MRC Epidemiology Unit, University of Cambridge
- Nicholas J. Wareham
- MRC Epidemiology Unit, University of Cambridge
- Claudia Langenberg
- MRC Epidemiology Unit, University of Cambridge
- Emmanouil Tsafantakis
- Anogia Medical Centre
- Maria Karaleftheri
- Echinos Medical Centre
- George Dedoussis
- Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens
- Anders Mälarstig
- Department of Medicine, Karolinska Institute
- James F. Wilson
- Centre for Global Health Research, Usher Institute, University of Edinburgh
- Arthur Gilly
- Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental Health
- Eleftheria Zeggini
- Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental Health
- DOI
- https://doi.org/10.1038/s41467-021-27387-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Serum proteins are easily accessible biomarkers and drug targets. Here, the authors use whole genome sequencing data to describe the genetic architecture of neurologically-relevant serum proteins and establish causal protein-neurological disease relationships.
