Communications Biology (Jan 2021)
Age-related injury responses of human oligodendrocytes to metabolic insults: link to BCL-2 and autophagy pathways
- Milton Guilherme Forestieri Fernandes,
- Julia Xiao Xuan Luo,
- Qiao-Ling Cui,
- Kelly Perlman,
- Florian Pernin,
- Moein Yaqubi,
- Jeffery A. Hall,
- Roy Dudley,
- Myriam Srour,
- Charles P. Couturier,
- Kevin Petrecca,
- Catherine Larochelle,
- Luke M. Healy,
- Jo Anne Stratton,
- Timothy E. Kennedy,
- Jack P. Antel
Affiliations
- Milton Guilherme Forestieri Fernandes
- Neuroimmunology Unit, Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University
- Julia Xiao Xuan Luo
- Neuroimmunology Unit, Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University
- Qiao-Ling Cui
- Neuroimmunology Unit, Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University
- Kelly Perlman
- Douglas Mental Health University Institute
- Florian Pernin
- Neuroimmunology Unit, Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University
- Moein Yaqubi
- Neuroimmunology Unit, Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University
- Jeffery A. Hall
- Department of Neurosurgery, McGill University Health Centre and Department of Neurology and Neurosurgery, McGill University
- Roy Dudley
- Department of Pediatric Neurosurgery, Montreal Children’s Hospital
- Myriam Srour
- Division of Pediatric Neurology, Montreal Children’s Hospital
- Charles P. Couturier
- Department of Neurosurgery, McGill University Health Centre and Department of Neurology and Neurosurgery, McGill University
- Kevin Petrecca
- Department of Neurosurgery, McGill University Health Centre and Department of Neurology and Neurosurgery, McGill University
- Catherine Larochelle
- Department of Neurology, University of Montreal
- Luke M. Healy
- Neuroimmunology Unit, Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University
- Jo Anne Stratton
- Neuroimmunology Unit, Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University
- Timothy E. Kennedy
- Department of Neurology and Neurosurgery; Department of Human Genetics and Bioengineering, McGill University
- Jack P. Antel
- Neuroimmunology Unit, Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University
- DOI
- https://doi.org/10.1038/s42003-020-01557-1
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 10
Abstract
Milton Fernandes et al. combine single cell RNA-sequencing and functional assays to show that human oligodendrocytes exhibit an age-dependent resistance to apoptosis. Their findings have important implications for the pathology and treatment of myelination disorders like multiple sclerosis.
