ROLE OF NEUREGULINS AND HEPATOCYTE GROWTH FACTOR IN THE DEVELOPMENT OF CASTRATION-RESISTANT PROSTATE CANCER

Abstract

The development of castration-resistant prostate cancer is an important problem of modern oncology. The review is focused on the system of growth factors – neuregulins and hepatocyte growth factor (HGF), direct pathligands of ErbB tyrosine protein kinases and hepatocyte growth factor receptor, c-Met, the activation of which triggers a cascade of signaling pathways, ending by the stimulation of proliferation of cancer cells, their migration under conditions of the development of tolerance to the treatment of castration.

Keywords

• prostate cancer, neuregulins, hgf, c-met, erbb