Nature Communications (Oct 2022)
P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells
- Sree Deepthi Muthukrishnan,
- Riki Kawaguchi,
- Pooja Nair,
- Rachna Prasad,
- Yue Qin,
- Maverick Johnson,
- Qing Wang,
- Nathan VanderVeer-Harris,
- Amy Pham,
- Alvaro G. Alvarado,
- Michael C. Condro,
- Fuying Gao,
- Raymond Gau,
- Maria G. Castro,
- Pedro R. Lowenstein,
- Arjun Deb,
- Jason D. Hinman,
- Frank Pajonk,
- Terry C. Burns,
- Steven A. Goldman,
- Daniel H. Geschwind,
- Harley I. Kornblum
Affiliations
- Sree Deepthi Muthukrishnan
- The UCLA Intellectual and Developmental Disabilities Research Center, David Geffen School of Medicine, UCLA
- Riki Kawaguchi
- The UCLA Intellectual and Developmental Disabilities Research Center, David Geffen School of Medicine, UCLA
- Pooja Nair
- The UCLA Intellectual and Developmental Disabilities Research Center, David Geffen School of Medicine, UCLA
- Rachna Prasad
- The UCLA Intellectual and Developmental Disabilities Research Center, David Geffen School of Medicine, UCLA
- Yue Qin
- The UCLA Intellectual and Developmental Disabilities Research Center, David Geffen School of Medicine, UCLA
- Maverick Johnson
- The UCLA Intellectual and Developmental Disabilities Research Center, David Geffen School of Medicine, UCLA
- Qing Wang
- The UCLA Intellectual and Developmental Disabilities Research Center, David Geffen School of Medicine, UCLA
- Nathan VanderVeer-Harris
- The UCLA Intellectual and Developmental Disabilities Research Center, David Geffen School of Medicine, UCLA
- Amy Pham
- The UCLA Intellectual and Developmental Disabilities Research Center, David Geffen School of Medicine, UCLA
- Alvaro G. Alvarado
- The UCLA Intellectual and Developmental Disabilities Research Center, David Geffen School of Medicine, UCLA
- Michael C. Condro
- The UCLA Intellectual and Developmental Disabilities Research Center, David Geffen School of Medicine, UCLA
- Fuying Gao
- The UCLA Intellectual and Developmental Disabilities Research Center, David Geffen School of Medicine, UCLA
- Raymond Gau
- The UCLA Intellectual and Developmental Disabilities Research Center, David Geffen School of Medicine, UCLA
- Maria G. Castro
- Department of Neurosurgery, and Department of Cell and Developmental Biology, University of Michigan Medical School
- Pedro R. Lowenstein
- Department of Neurosurgery, and Department of Cell and Developmental Biology, University of Michigan Medical School
- Arjun Deb
- Division of Cardiology, Department of Medicine, David Geffen School of Medicine, UCLA
- Jason D. Hinman
- Department of Neurology, David Geffen School of Medicine, UCLA
- Frank Pajonk
- Department of Radiation Oncology, David Geffen School of Medicine, UCLA
- Terry C. Burns
- Department of Neurological Surgery, Mayo Clinic
- Steven A. Goldman
- Center for Translational Neuromedicine, University of Rochester Medical Center
- Daniel H. Geschwind
- The UCLA Intellectual and Developmental Disabilities Research Center, David Geffen School of Medicine, UCLA
- Harley I. Kornblum
- The UCLA Intellectual and Developmental Disabilities Research Center, David Geffen School of Medicine, UCLA
- DOI
- https://doi.org/10.1038/s41467-022-33943-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
Therapeutic stress induces phenotypic plasticity in glioma stem cells although the mechanisms underlying this remain poorly understood. Here, the authors show that P300 mediates the radiation-induced vascular-like conversion of glioma stem cells to promote tumor recurrence.
