Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria

Brady A. Travis; Jared V. Peck; Raul Salinas; Brandon Dopkins; Nicholas Lent; Viet D. Nguyen; Mario J. Borgnia; Richard G. Brennan; Maria A. Schumacher

doi:10.1038/s41467-022-31573-0

Nature Communications (Jul 2022)

Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria

Brady A. Travis,
Jared V. Peck,
Raul Salinas,
Brandon Dopkins,
Nicholas Lent,
Viet D. Nguyen,
Mario J. Borgnia,
Richard G. Brennan,
Maria A. Schumacher

Affiliations

Brady A. Travis: Department of Biochemistry, 307 Research Dr., Box 3711, Duke University Medical Center
Jared V. Peck: Cryo-EM core, Department of Biochemistry and Biophysics, University of North Carolina
Raul Salinas: Department of Biochemistry, 307 Research Dr., Box 3711, Duke University Medical Center
Brandon Dopkins: Department of Biochemistry, 307 Research Dr., Box 3711, Duke University Medical Center
Nicholas Lent: Department of Biochemistry, 307 Research Dr., Box 3711, Duke University Medical Center
Viet D. Nguyen: Department of Biochemistry, 307 Research Dr., Box 3711, Duke University Medical Center
Mario J. Borgnia: Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services
Richard G. Brennan: Department of Biochemistry, 307 Research Dr., Box 3711, Duke University Medical Center
Maria A. Schumacher: Department of Biochemistry, 307 Research Dr., Box 3711, Duke University Medical Center

DOI: https://doi.org/10.1038/s41467-022-31573-0
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

Read online

How bacteria sense and respond to nitrogen is a key question in microbial physiology. This work unveils the mechanism by which the central nitrogen metabolic enzyme, glutamine synthetase, directly signals nitrogen availability to the GlnR regulator.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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