Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channel

Cameron L. Noland; Han Chow Chua; Marc Kschonsak; Stephanie Andrea Heusser; Nina Braun; Timothy Chang; Christine Tam; Jia Tang; Christopher P. Arthur; Claudio Ciferri; Stephan Alexander Pless; Jian Payandeh

doi:10.1038/s41467-022-28984-4

Nature Communications (Mar 2022)

Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channel

Cameron L. Noland,
Han Chow Chua,
Marc Kschonsak,
Stephanie Andrea Heusser,
Nina Braun,
Timothy Chang,
Christine Tam,
Jia Tang,
Christopher P. Arthur,
Claudio Ciferri,
Stephan Alexander Pless,
Jian Payandeh

Affiliations

Cameron L. Noland: Department of Structural Biology, Genentech Inc.
Han Chow Chua: Department of Drug Design and Pharmacology, University of Copenhagen
Marc Kschonsak: Department of Structural Biology, Genentech Inc.
Stephanie Andrea Heusser: Department of Drug Design and Pharmacology, University of Copenhagen
Nina Braun: Department of Drug Design and Pharmacology, University of Copenhagen
Timothy Chang: Department of BioMolecular Resources, Genentech Inc.
Christine Tam: Department of BioMolecular Resources, Genentech Inc.
Jia Tang: Department of Microchemistry, Proteomics & Lipidomics, Genentech Inc.
Christopher P. Arthur: Department of Structural Biology, Genentech Inc.
Claudio Ciferri: Department of Structural Biology, Genentech Inc.
Stephan Alexander Pless: Department of Drug Design and Pharmacology, University of Copenhagen
Jian Payandeh: Department of Structural Biology, Genentech Inc.

DOI: https://doi.org/10.1038/s41467-022-28984-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

Read online

NaX is an atypical member of the voltage-gated sodium channel family that may contribute to Na+ homeostasis. Here, the authors describe the structural and functional attributes of the human NaX channel to reveal new insights into its physiology.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal