Frontiers in Oncology (Feb 2022)

The Research Progress in Physiological and Pathological Functions of TRAF4

  • Xueqin Ruan,
  • Xueqin Ruan,
  • Rong Zhang,
  • Ruijuan Li,
  • Ruijuan Li,
  • Hongkai Zhu,
  • Hongkai Zhu,
  • Zhihua Wang,
  • Zhihua Wang,
  • Canfei Wang,
  • Canfei Wang,
  • Zhao Cheng,
  • Zhao Cheng,
  • Hongling Peng,
  • Hongling Peng,
  • Hongling Peng

DOI
https://doi.org/10.3389/fonc.2022.842072
Journal volume & issue
Vol. 12

Abstract

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Tumour necrosis factor receptor-associated factor 4 (TRAF4) is a member of the TRAF protein family, a cytoplasmic bridging molecule closely associated with various immune functions. The physiological processes of TRAF4 are mainly involved in embryonic development, cell polarity, cell proliferation, apoptosis, regulation of reactive oxygen species production. TRAF4 is overexpressed in a variety of tumors and regulates the formation and development of a variety of tumors. In this review, we summarize the physiological and pathological regulatory functions of TRAF4 and focus on understanding the biological processes involved in this gene, to provide a reference for further studies on the role of this gene in tumorigenesis and development.

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