Cryo-EM structure of the human histamine H1 receptor/Gq complex

Ruixue Xia; Na Wang; Zhenmei Xu; Yang Lu; Jing Song; Anqi Zhang; Changyou Guo; Yuanzheng He

doi:10.1038/s41467-021-22427-2

Nature Communications (Apr 2021)

Cryo-EM structure of the human histamine H1 receptor/Gq complex

Ruixue Xia,
Na Wang,
Zhenmei Xu,
Yang Lu,
Jing Song,
Anqi Zhang,
Changyou Guo,
Yuanzheng He

Affiliations

Ruixue Xia: Laboratory of Receptor Structure and Signaling, The HIT Center for Life Sciences, Harbin Institute of Technology
Na Wang: Laboratory of Receptor Structure and Signaling, The HIT Center for Life Sciences, Harbin Institute of Technology
Zhenmei Xu: Laboratory of Receptor Structure and Signaling, The HIT Center for Life Sciences, Harbin Institute of Technology
Yang Lu: Laboratory of Receptor Structure and Signaling, The HIT Center for Life Sciences, Harbin Institute of Technology
Jing Song: Laboratory of Receptor Structure and Signaling, The HIT Center for Life Sciences, Harbin Institute of Technology
Anqi Zhang: The HIT cryo-EM facility, Harbin Institute of Technology
Changyou Guo: The HIT cryo-EM facility, Harbin Institute of Technology
Yuanzheng He: Laboratory of Receptor Structure and Signaling, The HIT Center for Life Sciences, Harbin Institute of Technology

DOI: https://doi.org/10.1038/s41467-021-22427-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 9

Abstract

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Histamine receptors are effective targets for allergy treatments and antihistamines are the first choice of many allergic disorders, but the exact mechanism of agonist binding and receptor activation remain unknown. Here, the authors present the cryo-EM structure of histamine-bound H1R/Gq complex and propose a mechanism of ligand induced receptor activation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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