Frontiers in Immunology (Jun 2023)

CXCL8 and the peritoneal metastasis of ovarian and gastric cancer

  • Xuanrong Fu,
  • Qimeng Wang,
  • Hang Du,
  • Huifang Hao

DOI
https://doi.org/10.3389/fimmu.2023.1159061
Journal volume & issue
Vol. 14

Abstract

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CXCL8 is the most representative chemokine produced autocrine or paracrine by tumor cells, endothelial cells and lymphocytes. It can play a key role in normal tissues and tumors by activating PI3K-Akt, PLC, JAK-STAT, and other signaling pathways after combining with CXCR1/2. The incidence of peritoneal metastasis in ovarian and gastric cancer is extremely high. The structure of the peritoneum and various peritoneal-related cells supports the peritoneal metastasis of cancers, which readily produces a poor prognosis, low 5-year survival rate, and the death of patients. Studies show that CXCL8 is excessively secreted in a variety of cancers. Thus, this paper will further elaborate on the mechanism of CXCL8 and the peritoneal metastasis of ovarian and gastric cancer to provide a theoretical basis for the proposal of new methods for the prevention, diagnosis, and treatment of cancer peritoneal metastasis.

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