Nature Communications (Nov 2018)

Samarium(II) folding cascades involving hydrogen atom transfer for the synthesis of complex polycycles

  • Mateusz P. Plesniak,
  • Monserrat H. Garduño-Castro,
  • Philipp Lenz,
  • Xavier Just-Baringo,
  • David J. Procter

DOI
https://doi.org/10.1038/s41467-018-07194-x
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 9

Abstract

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Diversity-oriented synthesis is a valuable strategy to construct complex molecules of medicinal interest. Here, the authors show a folding cascade strategy to convert linear substrates into polycyclic compounds with multiple stereocentres by combining the reductive chemistry of SmI2 with 1,5-hydrogen atom transfer.