Nature Communications (Feb 2018)
Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells
- Luiz Carlos Caires-Júnior,
- Ernesto Goulart,
- Uirá Souto Melo,
- Bruno Henrique Silva Araujo,
- Lucas Alvizi,
- Alessandra Soares-Schanoski,
- Danyllo Felipe de Oliveira,
- Gerson Shigeru Kobayashi,
- Karina Griesi-Oliveira,
- Camila Manso Musso,
- Murilo Sena Amaral,
- Lucas Ferreira daSilva,
- Renato Mancini Astray,
- Sandra Fernanda Suárez-Patiño,
- Daniella Cristina Ventini,
- Sérgio Gomes da Silva,
- Guilherme Lopes Yamamoto,
- Suzana Ezquina,
- Michel Satya Naslavsky,
- Kayque Alves Telles-Silva,
- Karina Weinmann,
- Vanessa van der Linden,
- Helio van der Linden,
- João Ricardo Mendes de Oliveira,
- Nivia Maria Rodrigues Arrais,
- Adriana Melo,
- Thalita Figueiredo,
- Silvana Santos,
- Joanna Goes Castro Meira,
- Saulo Duarte Passos,
- Roque Pacheco de Almeida,
- Ana Jovina Barreto Bispo,
- Esper Abrão Cavalheiro,
- Jorge Kalil,
- Edécio Cunha-Neto,
- Helder Nakaya,
- Robert Andreata-Santos,
- Luis Carlos de Souza Ferreira,
- Sergio Verjovski-Almeida,
- Paulo Lee Ho,
- Maria Rita Passos-Bueno,
- Mayana Zatz
Affiliations
- Luiz Carlos Caires-Júnior
- Department of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP)
- Ernesto Goulart
- Department of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP)
- Uirá Souto Melo
- Department of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP)
- Bruno Henrique Silva Araujo
- Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM)
- Lucas Alvizi
- Department of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP)
- Alessandra Soares-Schanoski
- Butantan Institute
- Danyllo Felipe de Oliveira
- Department of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP)
- Gerson Shigeru Kobayashi
- Department of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP)
- Karina Griesi-Oliveira
- Department of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP)
- Camila Manso Musso
- Department of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP)
- Murilo Sena Amaral
- Butantan Institute
- Lucas Ferreira daSilva
- Department of Biochemistry, Institute of Chemistry, University of São Paulo (USP)
- Renato Mancini Astray
- Butantan Institute
- Sandra Fernanda Suárez-Patiño
- Butantan Institute
- Daniella Cristina Ventini
- Butantan Institute
- Sérgio Gomes da Silva
- Albert Einstein Hospital
- Guilherme Lopes Yamamoto
- Department of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP)
- Suzana Ezquina
- Department of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP)
- Michel Satya Naslavsky
- Department of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP)
- Kayque Alves Telles-Silva
- Department of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP)
- Karina Weinmann
- Department of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP)
- Vanessa van der Linden
- AACD
- Helio van der Linden
- Rehabilitation Center—Dr. Henrique Santillo
- João Ricardo Mendes de Oliveira
- Neuropsychiatry Department and KeizoAsami Laboratory, Federal University of Pernambuco (UFPE)
- Nivia Maria Rodrigues Arrais
- Department of Pediatrics, Federal University of Rio Grande do Norte (UFRN)
- Adriana Melo
- ISEA
- Thalita Figueiredo
- Department of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP)
- Silvana Santos
- Department of Biology, Paraíba State University (UEPB)
- Joanna Goes Castro Meira
- Federal University of Bahia (UFBA)
- Saulo Duarte Passos
- Infectious pediatric laboratory, Medicine School of Jundiaí
- Roque Pacheco de Almeida
- Division of Immunology and Molecular Biology Laboratory, Federal University of Sergipe (UFS)
- Ana Jovina Barreto Bispo
- Division of Immunology and Molecular Biology Laboratory, Federal University of Sergipe (UFS)
- Esper Abrão Cavalheiro
- Neuroscience laboratory, Department of Neurology and Neurosurgery, Federal University of São Paulo—UNIFESP/EPM
- Jorge Kalil
- Butantan Institute
- Edécio Cunha-Neto
- Heart Institute, Faculty of Medicine, University of São Paulo (USP)
- Helder Nakaya
- Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo (USP)
- Robert Andreata-Santos
- Vaccine Development Laboratory, Department of Microbiology, Institute of Biomedical Science, University of São Paulo (USP)
- Luis Carlos de Souza Ferreira
- Vaccine Development Laboratory, Department of Microbiology, Institute of Biomedical Science, University of São Paulo (USP)
- Sergio Verjovski-Almeida
- Butantan Institute
- Paulo Lee Ho
- Butantan Institute
- Maria Rita Passos-Bueno
- Department of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP)
- Mayana Zatz
- Department of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP)
- DOI
- https://doi.org/10.1038/s41467-017-02790-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Zika virus (ZIKV) infection can cause congenital Zika syndrome (CZS), but the underlying mechanisms are poorly understood. Here, the authors generate neural progenitor cells from dizygotic twins with a discordant phenotype regarding CZS and study their response to ZIKV infection.
