Developmental Cognitive Neuroscience (Dec 2024)
Quantifying brain development in the HEALthy Brain and Child Development (HBCD) Study: The magnetic resonance imaging and spectroscopy protocol
- Douglas C. Dean, III,
- M Dylan Tisdall,
- Jessica L. Wisnowski,
- Eric Feczko,
- Borjan Gagoski,
- Andrew L. Alexander,
- Richard A.E. Edden,
- Wei Gao,
- Timothy J. Hendrickson,
- Brittany R. Howell,
- Hao Huang,
- Kathryn L. Humphreys,
- Tracy Riggins,
- Chad M. Sylvester,
- Kimberly B. Weldon,
- Essa Yacoub,
- Banu Ahtam,
- Natacha Beck,
- Suchandrima Banerjee,
- Sergiy Boroday,
- Arvind Caprihan,
- Bryan Caron,
- Samuel Carpenter,
- Yulin Chang,
- Ai Wern Chung,
- Matthew Cieslak,
- William T. Clarke,
- Anders Dale,
- Samir Das,
- Christopher W. Davies-Jenkins,
- Alexander J. Dufford,
- Alan C. Evans,
- Laetitia Fesselier,
- Sandeep K. Ganji,
- Guillaume Gilbert,
- Alice M. Graham,
- Aaron T. Gudmundson,
- Maren Macgregor-Hannah,
- Michael P. Harms,
- Tom Hilbert,
- Steve C.N. Hui,
- M. Okan Irfanoglu,
- Steven Kecskemeti,
- Tobias Kober,
- Joshua M. Kuperman,
- Bidhan Lamichhane,
- Bennett A. Landman,
- Xavier Lecour-Bourcher,
- Erik G. Lee,
- Xu Li,
- Leigh MacIntyre,
- Cecile Madjar,
- Mary Kate Manhard,
- Andrew R. Mayer,
- Kahini Mehta,
- Lucille A. Moore,
- Saipavitra Murali-Manohar,
- Cristian Navarro,
- Mary Beth Nebel,
- Sharlene D. Newman,
- Allen T. Newton,
- Ralph Noeske,
- Elizabeth S. Norton,
- Georg Oeltzschner,
- Regis Ongaro-Carcy,
- Xiawei Ou,
- Minhui Ouyang,
- Todd B. Parrish,
- James J. Pekar,
- Thomas Pengo,
- Carlo Pierpaoli,
- Russell A. Poldrack,
- Vidya Rajagopalan,
- Dan W. Rettmann,
- Pierre Rioux,
- Jens T. Rosenberg,
- Taylor Salo,
- Theodore D. Satterthwaite,
- Lisa S. Scott,
- Eunkyung Shin,
- Gizeaddis Simegn,
- W. Kyle Simmons,
- Yulu Song,
- Barry J. Tikalsky,
- Jean Tkach,
- Peter C.M. van Zijl,
- Jennifer Vannest,
- Maarten Versluis,
- Yansong Zhao,
- Helge J. Zöllner,
- Damien A. Fair,
- Christopher D. Smyser,
- Jed T. Elison
Affiliations
- Douglas C. Dean, III
- Department of Pediatrics, University of Wisconsin–Madison, Madison, WI, USA; Department of Medical Physics, University of Wisconsin–Madison, Madison, WI, USA; Waisman Center, University of Wisconsin–Madison, Madison, WI, USA; Correspondence to: Departments of Pediatrics and Medical Physics, Waisman Center, University of Wisconsin–Madison, Madison, WI 53705, USA.
- M Dylan Tisdall
- Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
- Jessica L. Wisnowski
- Department of Pediatrics, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA, USA; Department of Radiology, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
- Eric Feczko
- Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA; Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA
- Borjan Gagoski
- Department of Radiology, Harvard Medical School, Boston, MA, USA; Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children’s Hospital, Boston, MA, USA
- Andrew L. Alexander
- Department of Medical Physics, University of Wisconsin–Madison, Madison, WI, USA; Waisman Center, University of Wisconsin–Madison, Madison, WI, USA; Department of Psychiatry, University of Wisconsin–Madison, Madison, WI, USA
- Richard A.E. Edden
- Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA
- Wei Gao
- Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Department of Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, USA
- Timothy J. Hendrickson
- Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA; Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN, USA; Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN, USA
- Brittany R. Howell
- Fralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA; Department of Human Development and Family Science, Virginia Tech, Blacksburg, VA, USA
- Hao Huang
- Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA
- Kathryn L. Humphreys
- Department of Psychology and Human Development, Vanderbilt University, Nashville, TN, USA
- Tracy Riggins
- Department of Psychology, University of Maryland, College Park, MD, USA
- Chad M. Sylvester
- Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA; Department of Radiology, Washington University in St. Louis, St. Louis, MO, USA; Taylor Family Institute for Innovative Psychiatric Research, Washington University in St. Louis, St. Louis, MO, USA
- Kimberly B. Weldon
- Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA
- Essa Yacoub
- Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA
- Banu Ahtam
- Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children’s Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA
- Natacha Beck
- McGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; McConnell Brain Imaging Centre, McGill University, Montréal, Québec, Canada
- Suchandrima Banerjee
- GE HealthCare, Menlo Park, CA, USA
- Sergiy Boroday
- McGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; McConnell Brain Imaging Centre, McGill University, Montréal, Québec, Canada
- Arvind Caprihan
- The Mind Research Network, Albuquerque, NM, USA
- Bryan Caron
- McGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; McConnell Brain Imaging Centre, McGill University, Montréal, Québec, Canada
- Samuel Carpenter
- Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA
- Yulin Chang
- Siemens Medical Solutions USA Inc, PA, USA
- Ai Wern Chung
- Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children’s Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA
- Matthew Cieslak
- Penn Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
- William T. Clarke
- Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
- Anders Dale
- Department of Radiology, University of California San Diego, La Jolla, CA, USA; Multimodal Imaging Laboratory, University of California San Diego, La Jolla, CA, USA; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA
- Samir Das
- McGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; McConnell Brain Imaging Centre, McGill University, Montréal, Québec, Canada
- Christopher W. Davies-Jenkins
- Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA
- Alexander J. Dufford
- Department of Psychiatry and Center for Mental Health Innovation, Oregon Health & Science University, Portland, OR, USA
- Alan C. Evans
- McGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; McConnell Brain Imaging Centre, McGill University, Montréal, Québec, Canada
- Laetitia Fesselier
- McGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; McConnell Brain Imaging Centre, McGill University, Montréal, Québec, Canada
- Sandeep K. Ganji
- MR Clinical Science, Philips Healthcare, Best, the Netherlands
- Guillaume Gilbert
- MR Clinical Science, Philips Healthcare, Mississauga, Ontario, Canada
- Alice M. Graham
- Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA
- Aaron T. Gudmundson
- Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA
- Maren Macgregor-Hannah
- Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA; Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN, USA
- Michael P. Harms
- Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA
- Tom Hilbert
- Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland,; Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland,; LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland,
- Steve C.N. Hui
- Developing Brain Institute, Children’s National Hospital, Washington, DC, USA; Department of Radiology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA
- M. Okan Irfanoglu
- Quantitative Medical Imaging Laboratory, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA,
- Steven Kecskemeti
- Waisman Center, University of Wisconsin–Madison, Madison, WI, USA
- Tobias Kober
- Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland,; Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland,; LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland,
- Joshua M. Kuperman
- Department of Radiology, University of California San Diego, La Jolla, CA, USA
- Bidhan Lamichhane
- Center for Health Sciences, Oklahoma State University, Tulsa, OK, USA
- Bennett A. Landman
- Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA
- Xavier Lecour-Bourcher
- McGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; McConnell Brain Imaging Centre, McGill University, Montréal, Québec, Canada
- Erik G. Lee
- Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA; Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN, USA; Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN, USA
- Xu Li
- Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA
- Leigh MacIntyre
- McGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; Lasso Informatics, Canada
- Cecile Madjar
- McGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; McConnell Brain Imaging Centre, McGill University, Montréal, Québec, Canada
- Mary Kate Manhard
- Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA; Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
- Andrew R. Mayer
- The Mind Research Network, Albuquerque, NM, USA
- Kahini Mehta
- Penn Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
- Lucille A. Moore
- Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA
- Saipavitra Murali-Manohar
- Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA
- Cristian Navarro
- Center for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, USA
- Mary Beth Nebel
- Center for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, USA; Department of Neurology, The Johns Hopkins School of Medicine, Baltimore, MD, USA
- Sharlene D. Newman
- Alabama Life Research Institute, University of Alabama, Tuscaloosa, AL, USA; Department of Psychology, University of Alabama, Tuscaloosa, AL, USA
- Allen T. Newton
- Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA; Monroe Carell Jr. Children's Hospital at Vandebrilt, Vanderbilt University Medical Center, Nashville, TN, USA
- Ralph Noeske
- GE HealthCare, Munich, Germany
- Elizabeth S. Norton
- Department of Communication Sciences and Disorders, School of Communication, Northwestern University, Evanston, IL, USA; Department of Medical Social Sciences, Feinberg School of Medicine, Chicago, IL, USA
- Georg Oeltzschner
- Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA
- Regis Ongaro-Carcy
- McGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; McConnell Brain Imaging Centre, McGill University, Montréal, Québec, Canada
- Xiawei Ou
- Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Arkansas Children's Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA
- Minhui Ouyang
- Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA
- Todd B. Parrish
- Department of Radiology, Feinberg School of Medicine, Chicago, IL, USA; Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA
- James J. Pekar
- Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA
- Thomas Pengo
- Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA; Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN, USA
- Carlo Pierpaoli
- Quantitative Medical Imaging Laboratory, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA,
- Russell A. Poldrack
- Department of Psychology, Stanford University, Stanford, CA, USA
- Vidya Rajagopalan
- Department of Pediatrics, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA, USA; Department of Radiology, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
- Dan W. Rettmann
- GE HealthCare, Rochester, MN, USA
- Pierre Rioux
- McGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; McConnell Brain Imaging Centre, McGill University, Montréal, Québec, Canada
- Jens T. Rosenberg
- Advanced Magnetic Resonance Imaging and Spectroscopy Facility, McKnight Brain Institute, University of Florida, Gainesville, FL, USA
- Taylor Salo
- Penn Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
- Theodore D. Satterthwaite
- Penn Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
- Lisa S. Scott
- Department of Psychology, University of Florida, Gainesville, FL, USA
- Eunkyung Shin
- Department of Psychology, Pennsylvania State University, University Park, PA, USA
- Gizeaddis Simegn
- Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA
- W. Kyle Simmons
- Department of Pharmacology and Physiology, Oklahoma State University Center for Health Sciences, Tulsa, OK, USA; OSU Biomedical Imaging Center, Oklahoma State University Center for Health Sciences, Tulsa, OK, USA
- Yulu Song
- Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA
- Barry J. Tikalsky
- Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA
- Jean Tkach
- Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA; Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
- Peter C.M. van Zijl
- Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA
- Jennifer Vannest
- Department of Communication Sciences and Disorders, University of Cincinnati, Cincinnati, OH, USA; Communication Sciences Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
- Maarten Versluis
- MR Clinical Science, Philips Healthcare, Best, the Netherlands
- Yansong Zhao
- MR Clinical Science, Philips Healthcare, Cleveland, OH, USA
- Helge J. Zöllner
- Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA
- Damien A. Fair
- Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA; Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA; Institute of Child Development, University of Minnesota, Minneapolis, MN, USA; Correspondence to: Department of Pediatrics, Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN 55455, USA.
- Christopher D. Smyser
- Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA; Department of Pediatrics, Washington University in St. Louis, St. Louis, MO, USA; Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA; Correspondence to: Departments of Neurology and Pediatrics, Washington University in St. Louis, St. Louis, MO, USA.
- Jed T. Elison
- Institute of Child Development, University of Minnesota, Minneapolis, MN, USA; Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA; Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA; Correspondence to: Institute of Child Development & Department of Pediatrics, Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN 55455, USA.
- Journal volume & issue
-
Vol. 70
p. 101452
Abstract
The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally and planned through early childhood. The acquisition of multimodal magnetic resonance-based brain development data is central to the study’s core protocol. However, application of Magnetic Resonance Imaging (MRI) methods in this population is complicated by technical challenges and difficulties of imaging in early life. Overcoming these challenges requires an innovative and harmonized approach, combining age-appropriate acquisition protocols together with specialized pediatric neuroimaging strategies. The HBCD MRI Working Group aimed to establish a core acquisition protocol for all 27 HBCD Study recruitment sites to measure brain structure, function, microstructure, and metabolites. Acquisition parameters of individual modalities have been matched across MRI scanner platforms for harmonized acquisitions and state-of-the-art technologies are employed to enable faster and motion-robust imaging. Here, we provide an overview of the HBCD MRI protocol, including decisions of individual modalities and preliminary data. The result will be an unparalleled resource for examining early neurodevelopment which enables the larger scientific community to assess normative trajectories from birth through childhood and to examine the genetic, biological, and environmental factors that help shape the developing brain.
