Frontiers in Cellular and Infection Microbiology (May 2024)

The footprint of gut microbiota in gallbladder cancer: a mechanistic review

  • Shujie Liu,
  • Weijian Li,
  • Weijian Li,
  • Weijian Li,
  • Weijian Li,
  • Jun Chen,
  • Jun Chen,
  • Jun Chen,
  • Jun Chen,
  • Maolan Li,
  • Maolan Li,
  • Maolan Li,
  • Maolan Li,
  • Yajun Geng,
  • Yajun Geng,
  • Yajun Geng,
  • Yajun Geng,
  • Yingbin Liu,
  • Yingbin Liu,
  • Yingbin Liu,
  • Yingbin Liu,
  • Wenguang Wu,
  • Wenguang Wu,
  • Wenguang Wu,
  • Wenguang Wu

DOI
https://doi.org/10.3389/fcimb.2024.1374238
Journal volume & issue
Vol. 14

Abstract

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Gallbladder cancer (GBC) is the most common malignant tumor of the biliary system with the worst prognosis. Even after radical surgery, the majority of patients with GBC have difficulty achieving a clinical cure. The risk of tumor recurrence remains more than 65%, and the overall 5-year survival rate is less than 5%. The gut microbiota refers to a variety of microorganisms living in the human intestine, including bacteria, viruses and fungi, which profoundly affect the host state of general health, disease and even cancer. Over the past few decades, substantial evidence has supported that gut microbiota plays a critical role in promoting the progression of GBC. In this review, we summarize the functions, molecular mechanisms and recent advances of the intestinal microbiota in GBC. We focus on the driving role of bacteria in pivotal pathways, such as virulence factors, metabolites derived from intestinal bacteria, chronic inflammatory responses and ecological niche remodeling. Additionally, we emphasize the high level of correlation between viruses and fungi, especially EBV and Candida spp., with GBC. In general, this review not only provides a solid theoretical basis for the close relationship between gut microbiota and GBC but also highlights more potential research directions for further research in the future.

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