A diet-microbial metabolism feedforward loop modulates intestinal stem cell renewal in the stressed gut

Yuanlong Hou; Wei Wei; Xiaojing Guan; Yali Liu; Gaorui Bian; Dandan He; Qilin Fan; Xiaoying Cai; Youying Zhang; Guangji Wang; Xiao Zheng; Haiping Hao

doi:10.1038/s41467-020-20673-4

Nature Communications (Jan 2021)

A diet-microbial metabolism feedforward loop modulates intestinal stem cell renewal in the stressed gut

Yuanlong Hou,
Wei Wei,
Xiaojing Guan,
Yali Liu,
Gaorui Bian,
Dandan He,
Qilin Fan,
Xiaoying Cai,
Youying Zhang,
Guangji Wang,
Xiao Zheng,
Haiping Hao

Affiliations

Yuanlong Hou: State Key Laboratory of Natural Medicines, Jiangsu Province Key Laboratory of Drug Metabolism, China Pharmaceutical University
Wei Wei: State Key Laboratory of Natural Medicines, Jiangsu Province Key Laboratory of Drug Metabolism, China Pharmaceutical University
Xiaojing Guan: State Key Laboratory of Natural Medicines, Jiangsu Province Key Laboratory of Drug Metabolism, China Pharmaceutical University
Yali Liu: State Key Laboratory of Natural Medicines, Jiangsu Province Key Laboratory of Drug Metabolism, China Pharmaceutical University
Gaorui Bian: Tianyi Health Sciences Institute (Zhenjiang)
Dandan He: State Key Laboratory of Natural Medicines, Jiangsu Province Key Laboratory of Drug Metabolism, China Pharmaceutical University
Qilin Fan: State Key Laboratory of Natural Medicines, Jiangsu Province Key Laboratory of Drug Metabolism, China Pharmaceutical University
Xiaoying Cai: State Key Laboratory of Natural Medicines, Jiangsu Province Key Laboratory of Drug Metabolism, China Pharmaceutical University
Youying Zhang: State Key Laboratory of Natural Medicines, Jiangsu Province Key Laboratory of Drug Metabolism, China Pharmaceutical University
Guangji Wang: State Key Laboratory of Natural Medicines, Jiangsu Province Key Laboratory of Drug Metabolism, China Pharmaceutical University
Xiao Zheng: State Key Laboratory of Natural Medicines, Jiangsu Province Key Laboratory of Drug Metabolism, China Pharmaceutical University
Haiping Hao: State Key Laboratory of Natural Medicines, Jiangsu Province Key Laboratory of Drug Metabolism, China Pharmaceutical University

DOI: https://doi.org/10.1038/s41467-020-20673-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Here, using a mouse model of chronic stress, the authors investigate how diet impacts stress and gut microbial structure and epithelial integrity and show that dietary raffinose metabolism to fructose couples stress-induced gut microbial remodeling to intestinal stem cell renewal and epithelial homeostasis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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