Nature Communications (Jan 2021)
Disulfide disruption reverses mucus dysfunction in allergic airway disease
- Leslie E. Morgan,
- Ana M. Jaramillo,
- Siddharth K. Shenoy,
- Dorota Raclawska,
- Nkechinyere A. Emezienna,
- Vanessa L. Richardson,
- Naoko Hara,
- Anna Q. Harder,
- James C. NeeDell,
- Corinne E. Hennessy,
- Hassan M. El-Batal,
- Chelsea M. Magin,
- Diane E. Grove Villalon,
- Gregg Duncan,
- Justin S. Hanes,
- Jung Soo Suk,
- David J. Thornton,
- Fernando Holguin,
- William J. Janssen,
- William R. Thelin,
- Christopher M. Evans
Affiliations
- Leslie E. Morgan
- Department of Medicine, School of Medicine, University of Colorado
- Ana M. Jaramillo
- Department of Medicine, School of Medicine, University of Colorado
- Siddharth K. Shenoy
- Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine
- Dorota Raclawska
- Department of Medicine, School of Medicine, University of Colorado
- Nkechinyere A. Emezienna
- Department of Medicine, School of Medicine, University of Colorado
- Vanessa L. Richardson
- Department of Medicine, School of Medicine, University of Colorado
- Naoko Hara
- Department of Medicine, School of Medicine, University of Colorado
- Anna Q. Harder
- Department of Medicine, School of Medicine, University of Colorado
- James C. NeeDell
- Department of Medicine, School of Medicine, University of Colorado
- Corinne E. Hennessy
- Department of Medicine, School of Medicine, University of Colorado
- Hassan M. El-Batal
- Department of Bioengineering, College of Engineering, Design, and Computing, University of Colorado
- Chelsea M. Magin
- Department of Medicine, School of Medicine, University of Colorado
- Diane E. Grove Villalon
- Parion Sciences, Inc.
- Gregg Duncan
- Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine
- Justin S. Hanes
- Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine
- Jung Soo Suk
- Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine
- David J. Thornton
- Wellcome Trust Centre for Cell-Matrix Research and the Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, The University of Manchester
- Fernando Holguin
- Department of Medicine, School of Medicine, University of Colorado
- William J. Janssen
- Department of Medicine, School of Medicine, University of Colorado
- William R. Thelin
- Parion Sciences, Inc.
- Christopher M. Evans
- Department of Medicine, School of Medicine, University of Colorado
- DOI
- https://doi.org/10.1038/s41467-020-20499-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 9
Abstract
In asthma, mucus plugging is an important cause of airflow obstruction, but it is not targeted by widely used bronchodilator and anti-inflammatory drugs. Here the authors show that reduction of disulfide bonds that hold mucin polymers together reverses asthma-like obstruction in mice.
