Nature Communications (Dec 2017)

Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors

  • Pau Martin-Malpartida,
  • Marta Batet,
  • Zuzanna Kaczmarska,
  • Regina Freier,
  • Tiago Gomes,
  • Eric Aragón,
  • Yilong Zou,
  • Qiong Wang,
  • Qiaoran Xi,
  • Lidia Ruiz,
  • Angela Vea,
  • José A. Márquez,
  • Joan Massagué,
  • Maria J. Macias

DOI
https://doi.org/10.1038/s41467-017-02054-6
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 15

Abstract

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Smad transcription factors are part of the TGF-β signal transduction pathways and are recruited to the genome by cell lineage-defining factors. Here, the authors identify specific Smad binding GC-rich motifs and provide structural information showing Smad3 and Smad4 bound to these motifs.