Engineering the lymph node environment promotes antigen-specific efficacy in type 1 diabetes and islet transplantation

Joshua M. Gammon; Sean T. Carey; Vikas Saxena; Haleigh B. Eppler; Shannon J. Tsai; Christina Paluskievicz; Yanbao Xiong; Lushen Li; Marian Ackun-Farmmer; Lisa H. Tostanoski; Emily A. Gosselin; Alexis A. Yanes; Xiangbin Zeng; Robert S. Oakes; Jonathan S. Bromberg; Christopher M. Jewell

doi:10.1038/s41467-023-36225-5

Nature Communications (Feb 2023)

Engineering the lymph node environment promotes antigen-specific efficacy in type 1 diabetes and islet transplantation

Joshua M. Gammon,
Sean T. Carey,
Vikas Saxena,
Haleigh B. Eppler,
Shannon J. Tsai,
Christina Paluskievicz,
Yanbao Xiong,
Lushen Li,
Marian Ackun-Farmmer,
Lisa H. Tostanoski,
Emily A. Gosselin,
Alexis A. Yanes,
Xiangbin Zeng,
Robert S. Oakes,
Jonathan S. Bromberg,
Christopher M. Jewell

Affiliations

Joshua M. Gammon: Fischell Department of Bioengineering, University of Maryland, College Park
Sean T. Carey: Fischell Department of Bioengineering, University of Maryland, College Park
Vikas Saxena: Department of Surgery, University of Maryland Medical School
Haleigh B. Eppler: Fischell Department of Bioengineering, University of Maryland, College Park
Shannon J. Tsai: Fischell Department of Bioengineering, University of Maryland, College Park
Christina Paluskievicz: Department of Surgery, University of Maryland Medical School
Yanbao Xiong: Department of Surgery, University of Maryland Medical School
Lushen Li: Department of Surgery, University of Maryland Medical School
Marian Ackun-Farmmer: Fischell Department of Bioengineering, University of Maryland, College Park
Lisa H. Tostanoski: Fischell Department of Bioengineering, University of Maryland, College Park
Emily A. Gosselin: Fischell Department of Bioengineering, University of Maryland, College Park
Alexis A. Yanes: Fischell Department of Bioengineering, University of Maryland, College Park
Xiangbin Zeng: Fischell Department of Bioengineering, University of Maryland, College Park
Robert S. Oakes: Fischell Department of Bioengineering, University of Maryland, College Park
Jonathan S. Bromberg: Department of Surgery, University of Maryland Medical School
Christopher M. Jewell: Fischell Department of Bioengineering, University of Maryland, College Park

DOI: https://doi.org/10.1038/s41467-023-36225-5
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 18

Abstract

Read online

Antigen-specific tolerance represents a promising strategy to treat type 1 diabetes and islet allograft rejection. Here, the authors deliver immune signals to lymph nodes to promote antigen-specific regulatory T cells and prevent disease in models of type 1 diabetes and allogenic islet transplantation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal