Clinical case of rheumatoid arthritis with antiphospholipid antibody syndrome

Abstract

The article presents a clinical case of development of secondary antiphospholipid syndrome (APS) with early active rheumatoid polyarthritis, complication in the form of acute deep vein thrombosis of forearm on the left and chronic left vein thrombosis of the lower extremity. Patient treatment with methotrexate has developed an infectious complication and resulting in the need to go to therapy of leflunomide. This therapy have positive effect. In a survey of the patient revealed a rare form of adrenal pheochromocytoma confirmed by computed tomography and measurements of plasma normetanephrine, but not accompanied an increase of blood pressure. This article discusses the modern classification of APS, pathogenesis, clinical and laboratory diagnostic criteria, methods of therapy as rheumatoid arthritis, and APS.

Keywords

• antiphospholipid syndrome
• antiphospholipid antibodies
• lupus anticoagulant
• anticardiolipin antibodies
• vascular thrombosis
• anticoagulants
• rheumatoid arthritis