Electroceutically induced subthalamic high-frequency oscillations and evoked compound activity may explain the mechanism of therapeutic stimulation in Parkinson’s disease

Musa Ozturk; Ashwin Viswanathan; Sameer A. Sheth; Nuri F. Ince

doi:10.1038/s42003-021-01915-7

Communications Biology (Mar 2021)

Electroceutically induced subthalamic high-frequency oscillations and evoked compound activity may explain the mechanism of therapeutic stimulation in Parkinson’s disease

Musa Ozturk,
Ashwin Viswanathan,
Sameer A. Sheth,
Nuri F. Ince

Affiliations

Musa Ozturk: Department of Biomedical Engineering, University of Houston
Ashwin Viswanathan: Department of Neurosurgery, Baylor College of Medicine
Sameer A. Sheth: Department of Neurosurgery, Baylor College of Medicine
Nuri F. Ince: Department of Biomedical Engineering, University of Houston

DOI: https://doi.org/10.1038/s42003-021-01915-7
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 14

Abstract

Read online

Ozturk et al investigate the modulations in local field potentials induced by electrical stimulation of the subthalamic nucleus (STN) at therapeutic and nontherapeutic frequencies in Parkinson’s disease (PD) patients undergoing DBS surgery. They find evidence to suggest that high-frequency STN-DBS tunes the neural oscillations to their healthy/treated state, similar to pharmacological treatment and thus could serve to recalibrate the dysfunctional circuitry generating PD symptoms.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal