Nature Communications (Mar 2019)

A TRIM71 binding long noncoding RNA Trincr1 represses FGF/ERK signaling in embryonic stem cells

  • Ya-Pu Li,
  • Fei-Fei Duan,
  • Yu-Ting Zhao,
  • Kai-Li Gu,
  • Le-Qi Liao,
  • Huai-Bin Su,
  • Jing Hao,
  • Kun Zhang,
  • Na Yang,
  • Yangming Wang

DOI
https://doi.org/10.1038/s41467-019-08911-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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FGF signaling through ERK is known to promote the differentiation of embryonic stem cells (ES cells). Here, the authors demonstrate that the lncRNA Trincr1 binds and represses TRIM71 in ES cells, leading to downregulation of SHCBP1 protein, the reduction of FGF/ERK signaling and the promotion of self-renewal.