Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4

Julio Gomez-Rodriguez; Françoise Meylan; Robin Handon; Erika T. Hayes; Stacie M. Anderson; Martha R. Kirby; Richard M. Siegel; Pamela L. Schwartzberg

doi:10.1038/ncomms10857

Nature Communications (Mar 2016)

Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4

Julio Gomez-Rodriguez,
Françoise Meylan,
Robin Handon,
Erika T. Hayes,
Stacie M. Anderson,
Martha R. Kirby,
Richard M. Siegel,
Pamela L. Schwartzberg

Affiliations

Julio Gomez-Rodriguez: National Human Genome Research Institute, National Institutes of Health
Françoise Meylan: National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health
Robin Handon: National Human Genome Research Institute, National Institutes of Health
Erika T. Hayes: National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health
Stacie M. Anderson: National Human Genome Research Institute, National Institutes of Health
Martha R. Kirby: National Human Genome Research Institute, National Institutes of Health
Richard M. Siegel: National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health
Pamela L. Schwartzberg: National Human Genome Research Institute, National Institutes of Health

DOI: https://doi.org/10.1038/ncomms10857
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

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The Tec family tyrosine kinase, Itk, is a component of the T-cell receptor essential for optimal Th2 responses in vivo. Here the authors show in human cells and mouse models that Itk is also needed for the production of IL-9, an important contributor to allergic asthma.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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