Congenital cytomegalovirus infection: ICCRG guidelines and management aspects that are at the stage of clinical trials

Abstract

Congenital cytomegalovirus (CMV) infection remains the least recognizable cause of sensoneural hearing loss and anomalies of the nervous system in newborns of developed countries. The lack of unified recommendations negatively affects the global effort to reduce the incidence of congenital anomalies associated with CMV. The own follow-up observations of children with nervous system malformations and sensoneural disorders, as well as the assessment of immunological response to CMV in women during pregnancy and neonatal period determined the in-depth analysis of contemporary world literature. The article presents directions for minimizing the risk of congenital CMV, which are realized in clinical recommendations based on the conclusions of leading world experts on the identification and management of congenital cytomegalovirus infection in pregnant and newborns, and also outlines management perspectives that are at the stage of clinical trials.

Keywords

• congenital cytomegalovirus infection
• cytomegalovirus
• children
• pregnant women
• newborns