Cardiovascular Diabetology (Oct 2010)

Plasma concentrations of osteopontin, but not thrombin-cleaved osteopontin, are associated with the presence and severity of nephropathy and coronary artery disease in patients with type 2 diabetes mellitus

  • Zhang Ruiyan,
  • Zhang Qi,
  • Wang Wei,
  • Lu Lin,
  • Sano Motoaki,
  • Yan Xiaoxiang,
  • Wang Lingjie,
  • Chen Qiujing,
  • Fukuda Keiichi,
  • Shen Weifeng

DOI
https://doi.org/10.1186/1475-2840-9-70
Journal volume & issue
Vol. 9, no. 1
p. 70

Abstract

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Abstract Background The aim of the present cross-sectional study was to assess possible associations between osteopontin (OPN), and thrombin-cleaved (N-half) OPN, and nephropathy and coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). Methods Plasma levels of OPN, N-half OPN, and high-sensitivity C-reactive protein (hsCRP) were determined in 301 diabetic patients with (n = 226) or without (n = 75) angiographically documented CAD (luminal diameter narrowing >50%), as well as in 75 non-diabetic controls with normal angiography. The estimated glomerular filtration rate (eGFR) was calculated in all patients. Results Plasma levels of OPN and hsCRP were significantly higher in patients with T2DM compared with controls. In addition, there was a higher occurrence of moderate renal insufficiency and lower eGFR in patients with T2DM (all P P Conclusions The results of the present study demonstrate that there is an independent association between plasma levels of OPN, but not N-half OPN, and the presence and severity of nephropathy and CAD in diabetes.