Nature Communications (Jul 2024)

SARS-CoV-2 serosurvey across multiple waves of the COVID-19 pandemic in New York City between 2020–2023

  • Juan Manuel Carreño,
  • Abram L. Wagner,
  • Brian Monahan,
  • Gagandeep Singh,
  • Daniel Floda,
  • Ana S. Gonzalez-Reiche,
  • Johnstone Tcheou,
  • Ariel Raskin,
  • Dominika Bielak,
  • Sara Morris,
  • Miriam Fried,
  • Temima Yellin,
  • Leeba Sullivan,
  • PARIS study group,
  • Emilia Mia Sordillo,
  • Aubree Gordon,
  • Harm van Bakel,
  • Viviana Simon,
  • Florian Krammer

DOI
https://doi.org/10.1038/s41467-024-50052-2
Journal volume & issue
Vol. 15, no. 1
pp. 1 – 10

Abstract

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Abstract Sero-monitoring provides context to the epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and changes in population immunity following vaccine introduction. Here, we describe results of a cross-sectional hospital-based study of anti-spike seroprevalence in New York City (NYC) from February 2020 to July 2022, and a follow-up period from August 2023 to October 2023. Samples from 55,092 individuals, spanning five epidemiological waves were analyzed. Prevalence ratios (PR) were obtained using Poisson regression. Anti-spike antibody levels increased gradually over the first two waves, with a sharp increase during the 3rd wave coinciding with SARS-CoV-2 vaccination in NYC resulting in seroprevalence levels >90% by July 2022. Our data provide insights into the dynamic changes in immunity occurring in a large and diverse metropolitan community faced with a new viral pathogen and reflects the patterns of antibody responses as the pandemic transitions into an endemic stage.