Curcumin Loaded onto Magnetic Mesoporous Material MCM-41 for Controlled and Released in Drug Delivery System

Abstract

In this work, the mesoporous silica nanoparticles (MSNs) of type MCM-41 were manufactured and modified with Fe3O4 to load curcumin (CUR) CUR@Fe3O4/MCM-41 as an efficient carrier in drug delivery systems. X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), Fourier Transform Infrared (FT-IR), and nitrogen adsorption-desorption isotherms were used to characterize the three samples: pure MCM-41, Fe3O4/MCM-41, & CUR@Fe3O4/MCM-41. Adsorption processes tests were carried out to determine the impact of various variables on the CUR load efficiency. These variables were the carrier dosage, pH, contact time, and initial CUR concentration. The maximal drug loading efficiencies (DL %) were 15.78 % and 22.98 %, respectively. According to the data, The Freundlich isotherm had a stronger correlation coefficient R2= 0.999 for MCM-41, while the Langmuir isotherm had a greater R2 of 0.9666 for Fe3O4/MCM-41. A pseudo-second-order kinetic model fits well with R2=0.9827 for MCM-41 and 0.9994 for Fe3O4/MCM-41. Phosphate Buffer Solution (PBS) with a pH of 7.4 was utilized to study CUR release behavior. According to the research, the maximum release for MCM-41 and Fe3O4/MCM-41 might be 74.1 % and 25.19 % after 72 h, respectively. Various kinetic release models were used, including First-order, Korsmeyer-Peppas, Hixson and Crowell, Higuchi, and Weibull. After 72h, the drug release data were fit using a Weibull kinetic model with an R2 of 0.944 and 0.764 for MCM-41 and Fe3O4/MCM-41, respectively.

Keywords

• curcumin
• drug delivery system
• fe3o4/mcm-41
• kinetic adsorption
• loading and release
• magnetic