Etiological factors of secretory and invasive diarrhea and measures to improve their treatment

Abstract

Acute intestinal infections (AII) remain one of the most important problems of children’s infectious pathology, as this disease is diagnosed with severe forms and the mortality remains in high rate. Among patients with acute intestinal infection, children account for 60-70%. Severe forms of the disease are still noted to lead to death in young children. In addition, in recent years, there has been an increase in acute intestinal infections, an increase in their clinical manifestations and a long-standing uneven trend. The severity of the disease often occurs due to the development of viral-bacterial and bacterial-bacterial Complex in young children. V.F. Uchaikina et al. According to (2004), the main criteria for diagnosis include the following forms: gastritis, enteritis, gastroenteritis, colitis, enterocolitis, gastroenterocolitis, distal colitis. In the initial period of the disease (until the results of laboratory tests are obtained), for the construction of rational etiotropic and pathogenetic-based therapy of the OII, it is necessary to first determine the pathological process(enteritis, colitis) by taking into account the severity of the disease (mild, moderate, severe). Even with the severe course of the disease in childhood, acute intestinal infections contribute to their formation, especially in children with a decrease in the health index, prone to other infectious and somatic diseases. About the role of OIC in the pathogenesis of chronic diseases of the digestive system, leading to overeating and decompensation of diseases of the gastrointestinal tract. At present, the etiological structure of the AII has changed. Now the leading role among them in the world is undoubtedly that 50-80% of AII in children belong to viruses. Currently, intestinal infections are associated with representatives of at least 8 different types of viral oylases: Reoviridae, Saliceviridae, Adenoviridae, Astroviridae, Picornoviridae, Cobovirus, Coronaviridae, ovoviridae, Picornaviridae agent. The etiology of viral diarrhea is similar in developed and developing countries. The spectrum of possible etiological agents of acute gastroenteritis continues to increase, since previously unknown viruses were detected in patients, but it is necessary to confirm their significance in this pathology. This article aims to study the etiotropic treatment measures aimed at inhibiting the development of acute intestinal infection bacteria or virus.