Pathology and Oncology Research (Aug 2022)

Clinicopathologic Features and Treatment of CD10-Positive Mantle Cell Lymphoma: A Case Report and Review of Literature

  • Christopher Hino,
  • Bryan Pham,
  • Austin L. Gray,
  • Jun Wang,
  • Dan Ran Castillo,
  • Mojtaba Akhtari,
  • Yan Liu

DOI
https://doi.org/10.3389/pore.2022.1610588
Journal volume & issue
Vol. 28

Abstract

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Mantle cell lymphoma (MCL) is a rare and aggressive non-Hodgkin’s B cell lymphoma characterized by the translocation t(11;14) (q13;32) and overexpression of CCND1. MCL is immunophenotypically identified as CD20+, CD5+, CyclinD1+, CD43+, CD10−, BCL6−, and CD23−. It is often distinguished from B cell lymphomas of germinal center cell origin by the absence of CD10 expression. Here we report the unique clinicopathologic features of a patient with CD10+ MCL with gastrointestinal involvement and review current literature identifying this unique immunophenotype.

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