Nature Communications (Mar 2021)
DNA methylation predicts age and provides insight into exceptional longevity of bats
- Gerald S. Wilkinson,
- Danielle M. Adams,
- Amin Haghani,
- Ake T. Lu,
- Joseph Zoller,
- Charles E. Breeze,
- Bryan D. Arnold,
- Hope C. Ball,
- Gerald G. Carter,
- Lisa Noelle Cooper,
- Dina K. N. Dechmann,
- Paolo Devanna,
- Nicolas J. Fasel,
- Alexander V. Galazyuk,
- Linus Günther,
- Edward Hurme,
- Gareth Jones,
- Mirjam Knörnschild,
- Ella Z. Lattenkamp,
- Caesar Z. Li,
- Frieder Mayer,
- Josephine A. Reinhardt,
- Rodrigo A. Medellin,
- Martina Nagy,
- Brian Pope,
- Megan L. Power,
- Roger D. Ransome,
- Emma C. Teeling,
- Sonja C. Vernes,
- Daniel Zamora-Mejías,
- Joshua Zhang,
- Paul A. Faure,
- Lucas J. Greville,
- Steve Horvath
Affiliations
- Gerald S. Wilkinson
- Department of Biology, University of Maryland
- Danielle M. Adams
- Department of Biology, University of Maryland
- Amin Haghani
- Department of Human Genetics, David Geffen School of Medicine, University of California
- Ake T. Lu
- Department of Human Genetics, David Geffen School of Medicine, University of California
- Joseph Zoller
- Department of Biostatistics, Fielding School of Public Health, University of California
- Charles E. Breeze
- Altius Institute for Biomedical Sciences
- Bryan D. Arnold
- Department of Biology, Illinois College
- Hope C. Ball
- Department of Anatomy and Neurobiology, Northeast Ohio Medical University
- Gerald G. Carter
- Department of Evolution, Ecology and Organismal Biology, The Ohio State University
- Lisa Noelle Cooper
- Department of Anatomy and Neurobiology, Northeast Ohio Medical University
- Dina K. N. Dechmann
- Department of Migration, Max Planck Institute of Animal Behavior
- Paolo Devanna
- Neurogenetics of Vocal Communication Group, Max Planck Institute for Psycholinguistics
- Nicolas J. Fasel
- Department of Ecology and Evolution, University of Lausanne
- Alexander V. Galazyuk
- Department of Anatomy and Neurobiology, Northeast Ohio Medical University
- Linus Günther
- Museum für Naturkunde, Leibniz-Institute for Evolution and Biodiversity Science
- Edward Hurme
- Department of Biology, University of Maryland
- Gareth Jones
- School of Biological Sciences, University of Bristol
- Mirjam Knörnschild
- Smithsonian Tropical Research Institute
- Ella Z. Lattenkamp
- Neurogenetics of Vocal Communication Group, Max Planck Institute for Psycholinguistics
- Caesar Z. Li
- Department of Biostatistics, Fielding School of Public Health, University of California
- Frieder Mayer
- Museum für Naturkunde, Leibniz-Institute for Evolution and Biodiversity Science
- Josephine A. Reinhardt
- Department of Biology, State University of New York
- Rodrigo A. Medellin
- Instituto de Ecología, Universidad Nacional Autónoma de México, Ciudad Universitaria
- Martina Nagy
- Museum für Naturkunde, Leibniz-Institute for Evolution and Biodiversity Science
- Brian Pope
- Lubee Bat Conservancy
- Megan L. Power
- School of Biology and Environmental Science, University College Dublin
- Roger D. Ransome
- School of Biological Sciences, University of Bristol
- Emma C. Teeling
- School of Biology and Environmental Science, University College Dublin
- Sonja C. Vernes
- Neurogenetics of Vocal Communication Group, Max Planck Institute for Psycholinguistics
- Daniel Zamora-Mejías
- Instituto de Ecología, Universidad Nacional Autónoma de México, Ciudad Universitaria
- Joshua Zhang
- Department of Human Genetics, David Geffen School of Medicine, University of California
- Paul A. Faure
- Department of Psychology, Neuroscience and Behaviour, McMaster University
- Lucas J. Greville
- Department of Psychology, Neuroscience and Behaviour, McMaster University
- Steve Horvath
- Department of Human Genetics, David Geffen School of Medicine, University of California
- DOI
- https://doi.org/10.1038/s41467-021-21900-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
DNA methylation profiles from 26 bat species accurately predicts chronological age, while longevity-related methylation patterns across the genome suggest that bat longevity results from augmented immune response and cancer suppression.
