Frontiers in Pharmacology (Aug 2024)

Pro- and anti-inflammatory cytokines: the hidden keys to autoimmune gastritis therapy

  • Greta Cascetta,
  • Giorgia Colombo,
  • Gianmarco Eremita,
  • Joe G. N. Garcia,
  • Marco Vincenzo Lenti,
  • Antonio Di Sabatino,
  • Cristina Travelli

DOI
https://doi.org/10.3389/fphar.2024.1450558
Journal volume & issue
Vol. 15

Abstract

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Autoimmune gastritis (AIG) is an autoimmune disorder characterized by the destruction of gastric parietal cells and atrophy of the oxyntic mucosa which induces intrinsic factor deficiency and hypo-achlorhydria. AIG predominantly affects the antral mucosa with AIG patients experiencing increased inflammation and a predisposition toward the development of gastric adenocarcinoma and type I neuroendocrine tumors. The exact pathogenesis of this autoimmune disorder is incompletely understood although dysregulated immunological mechanisms appear to major contributors. This review of autoimmune gastritis, an unmet medical need, summarizes current knowledge on pro- and anti-inflammatory cytokines and strategies for the discovery of novel biomarkers and potential pharmacological targets.

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