Nature Communications (May 2018)
Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines
- Chunshuai Huang,
- Chunfang Yang,
- Wenjun Zhang,
- Liping Zhang,
- Bidhan Chandra De,
- Yiguang Zhu,
- Xiaodong Jiang,
- Chunyan Fang,
- Qingbo Zhang,
- Cheng-Shan Yuan,
- Hung-wen Liu,
- Changsheng Zhang
Affiliations
- Chunshuai Huang
- Key Laboratory of Tropical Marine Bio-resources and EcologyGuangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences
- Chunfang Yang
- Key Laboratory of Tropical Marine Bio-resources and EcologyGuangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences
- Wenjun Zhang
- Key Laboratory of Tropical Marine Bio-resources and EcologyGuangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences
- Liping Zhang
- Key Laboratory of Tropical Marine Bio-resources and EcologyGuangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences
- Bidhan Chandra De
- Key Laboratory of Tropical Marine Bio-resources and EcologyGuangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences
- Yiguang Zhu
- Key Laboratory of Tropical Marine Bio-resources and EcologyGuangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences
- Xiaodong Jiang
- Key Laboratory of Tropical Marine Bio-resources and EcologyGuangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences
- Chunyan Fang
- Key Laboratory of Tropical Marine Bio-resources and EcologyGuangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences
- Qingbo Zhang
- Key Laboratory of Tropical Marine Bio-resources and EcologyGuangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences
- Cheng-Shan Yuan
- Key Laboratory of Tropical Marine Bio-resources and EcologyGuangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences
- Hung-wen Liu
- Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy and Department of Chemistry, University of Texas at Austin
- Changsheng Zhang
- Key Laboratory of Tropical Marine Bio-resources and EcologyGuangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-018-04487-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 10
Abstract
Benzofluorene-containing angucyclines, bacterial natural compounds with potential use as therapeutics/antibiotics, occur as dimers. Here, the authors elucidated the dimerization mechanism which turned out to work spontaneously, without enzymatic catalysis.
